The game's main storyline begins during the A-Day. On the side of villainy are Taskmaster (Tony Masters), Abomination (Emil Blonsky), MODOK (George Tarleton), Monica Rappaccini, and Loki. The game's supporting NPCs include the Hank Pym, J.A.R.V.I.S, Phil Sheldon, Nick Fury, Maria Hill, Dum Dum Dugan, Dante Pertuz, and Cerise. Other superheroes who will be available after the initial release include Hawkeye (Clint Barton), Black Panther (T'Challa), and Hawkeye II (Kate Bishop). For PlayStation owners of the game, Spider-Man (Peter Parker) will be a console-exclusive playable character.
The initially playable characters who form the Avengers team are Captain America (Steve Rogers), Iron Man (Tony Stark), The Hulk (Bruce Banner), Thor, Black Widow (Natasha Romanoff), and Ms. Marvel's Avengers features a roster of playable and non-playable characters from the Marvel Universe as well as a few original ones. It will also be released on the PlayStation 5 and Xbox Series X with PlayStation 4 and Xbox One owners being able to upgrade to the next-gen version for free. Marvel's Avengers was released for Microsoft Windows, PlayStation 4, Stadia, and Xbox One.